Sathish Kumar Natarajan

Sathish Kumar Natarajan photo portrait

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Sathish Kumar Natarajan

Assistant Professor

BS, Biochemistry, University of Madras, Tamilnadu, India, 1999
MS, Biochemistry, University of Madras, Tamilnadu, India, 2001
Ph.D., Biomedical Sciences, Dr. MGR Medical University, Tamilnadu, India, 2008

Dr. Natarajan has strong background and expertise in signaling pathways of liver lipotoxicity during non-alcoholic fatty liver disease (NAFLD). Dr. Natarajan’s postdoctoral work demonstrated for the first time that saturated free fatty acids induce cholangiocyte lipoapoptosis via the activation of MAP Kinases (p38 and ERK) and forkhead family of transcription factor Class O 3(FoxO3) and its downstream targets like p53-upregulated modulator of apoptosis (PUMA). Further, Dr. Natarajan had earlier demonstrated that placental mitochondrial dysfunction and oxidative stress as a cause for liver injury in patients with acute fatty liver of pregnancy.

 Currently, Dr. Natarajan's lab is interested in elucidating the mechanism of 3-hydroxy-fatty acid-induced placental lipoapoptosis, linking lipotoxicity to placental injury and acute fatty liver of pregnancy.


Areas of Expertise:

    • Studied pathways of liver lipotoxicity in non-alcoholic fatty liver disease (NAFLD)
    • Established that proline and pipecolate metabolism promote cell survival
    • Determined the mechanisms by which dysfunction in placental metabolism affects maternal liver health.
    • Demonstrated that liver cirrhosis results in intestinal and renal dysfunction

Professional Highlights

Honors and Recognition
2015 - Travel Award to attend AASLD and Industry Colloquium: Novel Targets and Therapies in Liver Disease2006 - Young Scientist Travel Award, 20th IUBMB Conference2004 - Shakuntala Amir Chand Prize, Indian Council of Medical Research, Govt. of India
Experience
2001 - 2008 Graduate Student, Christian Medical College, Vellore, Tamilnadu, India2008 - 2012 Postdoctoral Research Associate, University of Nebraska, Lincoln, NE2012 - 2014 Postdoctoral Research Associate, University of Nebraska Medical Center, Omaha, NE2014 - 2015 Instructor, University of Nebraska Medical Center, Omaha, NE2016 - Assistant Professor, University of Nebraska-Lincoln, NE
Memberships
2014 - Member, American Association for the Study of Liver Disease2015 - Member, American Association for the Advancement of Science2015 - Consulting Editor to Journal of Hepatic Medicine: Evidence and Research, and Cell Heath and Cytoskeleton