External Website:
http://redoxbiologycenter.unl.edu/dmitrifomenkohomepage

The thiol-dependent redox regulation is among the major, but poorly investigated biological processes. A direct link of thiol redox processes to cancer, ging-related diseases and metabolic diseases and other pathologies has been demonstrated recently. My research interests include: 1) The set of ER thiol oxidoreductases and selenoproteins with unknown function, which are associated with various disorders (cancer, mental retardation, cataract, diabetes, etc). Our goal is to identify biological function of these proteins and explore their roles in ER redox homeostasis and pathology development. 2) Roles and mechanism of hydrogen peroxide mediated signaling. This type of signaling is an essential, but uninvestigated phenomenon, which determines redox homeostasis in the cell and tightly connected to general metabolic processes. We demonstrated the role of thiol peroxidases as messengers in hydrogen peroxide signaling process. Our goal is to identify a final thiol peroxidases targets in signaling machinery, investigate signaling pathways, which are controlled by thiol oxidoreductases, and clarify link between hydrogen peroxide mediated signaling and metabolic disorders.