Ed Harris, Cliff Stains, PhD NPOD Investigator


Former Seed Grant Project Leaders 2015-2016

Harris (Biochemistry-UNL), Stains (Chemistry-now at University of Virginia)

Phone: 402.472.7468 (Harris), 434.297.6810 (Stains)  |  Email: eharris5@unl.edu , cstains@virginia.edu

External Website:

Harris: The focus of my post-doctoral research is the cloning and characterization of the Stabilin receptors expressed in the liver sinusoidal endothelial cells (LSECs).  This work has been carried over to my research appointment at UNL in which we have determined that the Stabilin receptors are critical players in the catabolism of natural/synthetic heparins and anti-sense oligonucleotides.  A recent R01 by the National Heart Lung and Blood Institute has been awarded to the Harris lab and collaborators to further investigate this topic.  Since we have established many of the ECM ligands in plasma are regulated by the Stabilins, we asked how this changes during fatty liver which affects about 1/3 of the adult population in the US.  The effects of fatty liver have not been well-characterized for the metabolism of LSECs and we are currently developing a mouse model to monitor the changes that occur in receptor turnover and activity during progression of fatty liver.

Stains: Our laboratory conducts research at the interface of chemistry and biology. We are particularly interested in employing chemical tools and design principles to investigate biological systems. Our research program is centered on three areas involving: 1) new methodologies for constructing designer signaling networks, 2) fundamental studies of protein misfolding, and 3) the development and application of bioprobes. The long term goal of these projects is to provide fundamental insights into biological processes. These multidisciplinary efforts are supported by a combination of approaches including synthesis, protein design and evolution, bioanalytical chemistry, and molecular biology.