Ed Harris, PhD NPOD Investigator
Assistant Professor - Seed Grant Project Leader
N133 Beadle Center
Phone: 402.472.7468 | Email: email@example.com
The focus of my post-doctoral research is the cloning and characterization of the Stabilin receptors expressed in the liver sinusoidal endothelial cells (LSECs). This work has been carried over to my research appointment at UNL in which we have determined that the Stabilin receptors are critical players in the catabolism of natural/synthetic heparins and anti-sense oligonucleotides. A recent R01 by the National Heart Lung and Blood Institute has been awarded to the Harris lab and collaborators to further investigate this topic. Since we have established many of the ECM ligands in plasma are regulated by the Stabilins, we asked how this changes during fatty liver which affects about 1/3 of the adult population in the US. The effects of fatty liver have not been well-characterized for the metabolism of LSECs and we are currently developing a mouse model to monitor the changes that occur in receptor turnover and activity during progression of fatty liver.