External Website:
https://cehs.unl.edu/nhs/faculty/janos-zempleni/

My laboratory has 20+ years of experience in nutrient signaling, and its roles in human disease. Gene regulation by epigenetic mechanisms and non-coding RNAs has always been of particular interest to our group. We have made seminal discoveries in these areas, including covalent modification of chromatin proteins by vitamins, the role of holocarboxylase synthetase in orchestrating a multiprotein gene repression complex in human chromatin, and the absorption of dietary microRNA and its effects on gene expression in humans.