Jung Yul Lim, PhD NPOD Investigator
Associate Professor - PROJECT LEADER 11 (Former Seed Grant Project Leader 2018-2019)
Mechanical and Materials Engineering
W317.3 Nebraska Hall
Phone: 402.472.2480 | Email: firstname.lastname@example.org
The overall goal of our research group is to regulate cell function and fate via applying mechanical signals (mechanical stretch, fluid shear) and biomaterial cues (micro/nanoscale substrates). We further aim to reveal the role of focal adhesion, cytoskeletal tension, nucleoskeleton-cytoskeleton linkage, cell-cell junction, and immune response in cells sensing and responding to mechanical signals and biomaterials. The crosstalk between engineered extracellular environments and molecular signaling cascades in cell mechanotransduction and cell-biomaterial interaction will provide high impact mechanistic data for mechanobiology, biomaterials science, and regenerative medicine. For this NPOD Seed Grant Project, we propose to apply cellular mechanotransduction approach to adipocytes which have not been traditionally highlighted as mechanosensitive. Our adipocyte mechanobiology approach may provide a new insight into how to control obesity and related metabolic diseases.