Sathish Kumar Natarajan

Sathish Kumar Natarajan, PhD NPOD Investigator


Assistant Professor - Project Leader 10

Nutrition and Health Sciences
UNL
FYH 229
Lincoln NE 68583-0806

Phone: 402.472.7227  |  Email: snatarajan2@unl.edu

External Website:

Research Interests: 

I am in the early stage of my career starting my independent research program focusing on acute fatty liver of pregnancy. My research achievement includes 23 peer-reviewed publications, among which 16 are first-authored manuscripts published in journals like Hepatology, Free Radical Biology & Medicine, Archives of Biochem Biophys, and Journal of Gastroenterology and Hepatology. These articles were cited more than 529  in 350 documents including editorial comments. I am well-trained in mechanisms of cell injury and protection and will use my knowledge of metabolism and lipoapoptosis to elucidate signaling in acute fatty liver of pregnancy. I have established that placental fatty acid oxidation defects result in the release of toxic fatty acid metabolites and damage the maternal liver in acute fatty liver of pregnancy. As a recognition for my contribution, I have been invited as an ad hoc reviewer for the Well-being women foundation, London UK and as a consulting editor to Journal of Hepatic Medicine:Evidence & Research  and Cell Health and Cytoskeleton. In my first postdoctoral training in the laboratory of Dr. Donald Becker, I have studied and provided compelling pieces of evidence that proline supplementation can protect cells against cell death by activating the Akt-FoxO3 signaling pathway. In 2012, I decided that I wanted to pursue the rest of my career in my home field of hepatology and gastroenterology. For this reason, I moved to the University of Nebraska Medical Center to obtain further training with my mentor, Dr. Justin Mott. In 3 and half years, I have published 5 articles and currently working on 2 first authored manuscripts:1) on the role of microRNA 34a in cholangiocyte lipoapoptosis and 2), identified the mechanism of palmitoleate protecting against palmitate-induced cholangiocyte lipoapoptosis, and several co-authored manuscripts. Currently, joined UNL as an Assistant Professor and have been funded by NPOD seed grant program to elucidate the mechanism of hydroxy-fatty acid-induced hepatocyte and placental cell lipoapoptosis.