Sathish Kumar Natarajan
Sathish Kumar NatarajanAssistant Professor
BS, Biochemistry, University of Madras, Tamilnadu, India, 1999
MS, Biochemistry, University of Madras, Tamilnadu, India, 2001
Ph.D., Biomedical Sciences, Dr. MGR Medical University, Tamilnadu, India, 2008
Dr. Natarajan has strong background and expertise in signaling pathways of liver lipotoxicity during non-alcoholic fatty liver disease (NAFLD). Dr. Natarajan’s postdoctoral work demonstrated for the first time that saturated free fatty acids induce cholangiocyte lipoapoptosis via the activation of MAP Kinases (p38 and ERK) and forkhead family of transcription factor Class O 3(FoxO3) and its downstream targets like p53-upregulated modulator of apoptosis (PUMA). Further, Dr. Natarajan had earlier demonstrated that placental mitochondrial dysfunction and oxidative stress as a cause for liver injury in patients with acute fatty liver of pregnancy.
Currently, Dr. Natarajan's lab is interested in elucidating the mechanism of 3-hydroxy-fatty acid-induced placental lipoapoptosis, linking lipotoxicity to placental injury and acute fatty liver of pregnancy.
Areas of Expertise:
• Studied pathways of liver lipotoxicity in non-alcoholic fatty liver disease (NAFLD)
• Established that proline and pipecolate metabolism promote cell survival
• Determined the mechanisms by which dysfunction in placental metabolism affects maternal liver health.
• Demonstrated that liver cirrhosis results in intestinal and renal dysfunction